According to a study conducted on hospitalized patients in Telangana, vitamin D deficiency is more common in children with tuberculosis (TB) than children not infected with the bacterial disease. The study, recently published in the journal CURIOUS, also found that a severe form of vitamin D deficiency — less than 10 nanograms per milliliter (ng/mL) — is more common in children with TB.
The team, including researchers from Osmania Medical College (OMC) and Government Medical College, Siddipet, conducted the study at Nilufar Hospital, Telangana, a tertiary care center over a period of one year and five months. A total of 70 children with tuberculosis between 6 months and 12 years of age were included in the study.
Participants were divided into three age groups: 1–4 years, 5–8 years, and 9–12 years. “The mean level of vitamin D in our study was 10.43 ng/ml in cases and 22.84 ng/ml in controls,” the study authors noted. “The study showed that vitamin D deficiency (VDD) was higher in children with tuberculosis than in controls. In addition, severe forms of VDD were more common in children with TB,” they added.
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The researchers noted that clinicians should be aware of associated malnutrition and low socioeconomic status as risk factors for severe vitamin D deficiency among them. Tuberculosis (TB) is one of the most devastating and widespread infections in the world. It is a major cause of morbidity and mortality, especially in developing countries, the researchers said.
TB is caused by mycobacteria. Mycobacterium tuberculosis is the most frequently found organism, and to some extent, M. Bovis and M. African An imbalance between mycobacterial virulence and host immunity determines disease progression, the researchers added.
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